C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 19/00 (2006.01) A61K 35/14 (2006.01) A61K 39/00 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01) C07K 14/705 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) C12N 5/0783 (2010.01) A61K 48/00 (2006.01)
Patent
CA 2735456
Integration of costimulatory signaling domains within a tumor targeting chimeric antigen receptor (CAR), such as the IL13R.alpha.2 specific IL13- zetakine (EL13.zeta.), enhances T cell-mediated responses against tumors even in the absence of expressed ligands for costimulatory receptors.
La présente invention concerne lintégration de domaines de signalisation costimulateurs dans un récepteur dantigène chimère (CAR) ciblant une tumeur, tel que IL13-zétakine spécifique de IL13Ra2 (IL13?), qui augmente les réponses véhiculées par les lymphocytes T contre des tumeurs, même en labsence de ligands exprimés pour des récepteurs costimulateurs.
City Of Hope
Osler Hoskin & Harcourt Llp
LandOfFree
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