C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/14 (2006.01) C07D 243/04 (2006.01) C07D 403/06 (2006.01) C07F 9/62 (2006.01) C07F 9/645 (2006.01) C07F 9/653 (2006.01) C07F 9/655 (2006.01) C07F 9/6558 (2006.01) C07F 9/6561 (2006.01) C12N 9/16 (2006.01) C12Q 1/34 (2006.01) C12Q 1/44 (2006.01) C12Q 1/70 (2006.01) G01N 33/569 (2006.01)
Patent
CA 2481449
Methods are provided for identifying anti-HIV therapeutic compounds substituted with carboxyl ester or phosphonate ester groups. Libraries of such compounds are screened optionally using the novel enzyme GS-7340 Ester Hydrolase. Compositions and methods relating to GS-7340 Ester Hydrolase also are provided.
La présente invention concerne des techniques permettant d'identifier des composés thérapeutiques anti-VIH substitués avec des groupes ester carboxyle ou ester phosphonate. On crible des bibliothèques de ces composés éventuellement en utilisant la nouvelle enzyme hydrolase ester GS-7340. Cette invention concerne aussi des compositions et des techniques relatives à l'hydrolase ester GS-7340.
Birkus Gabriel
Chen James M.
Chen Xiaowu
Cihlar Tomas
Eisenberg Eugene J.
Gilead Sciences Inc.
Robic
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