Method and compositions for increasing the serum half-life...

Details Method and compositions for increasing the serum half-life... Method and compositions for increasing the serum half-life...

A - Human Necessities

61

K

A61K 47/48 (2006.01)

Patent

CA 2184002

Compositions and methods are provided for increasing the serum half-life of a pharmacologically active agent. The novel compositions are covalent conjugates of the selected pharmacologically active agent and a transthyretin-binding ligand such as tetraiodothyroacetic acid, 2,4,6-triiodophenol, flufenamic acid, or the like.

Compositions et procédés permettant de prolonger la demi-vie sérique d'un agent à activité pharmacologique. Ces nouvelles compositions sont des conjugués covalents de l'agent à activité pharmacologique choisi et d'un ligand de liaison de transthyrétine tel que l'acide tétra-iodothyroacétique, 2,4,6-tri-iodophénol, l'acide flufénamique ou autre.

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