C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 209/10 (2006.01) A61K 31/40 (2006.01) A61K 31/404 (2006.01) C07D 209/08 (2006.01) C07D 209/14 (2006.01) C07D 403/10 (2006.01) C07D 403/14 (2006.01)
Patent
CA 2224103
The present invention relates to methods and compositions for the inhibition of adaptor protein/protein tyrosine kinase protein interactions, especially wherein those interactions involving a protein tyrosine kinase capable of complexing with a member of the SH2-and/or SH3-containing family of adaptor proteins are associated with a cell proliferative disorder. Specifically, the present invention relates to particular compounds, especially quinazoline derivative compounds, and methods utilizing such compounds.
La présente invention concerne des méthodes et des composés permettant l'inhibition des interactions protéine adaptatrice/tyrosine kinase, en particulier quand ces interactions, mettant en jeu une tyrosine kinase protéique capable de former des complexes avec un membre de la famille des protéines adaptatrices renfermant SH2 et/ou SH3, sont associées à une affection cellulaire proliférative. La présente invention concerne spécifiquement des composés particuliers, entre autres les composés dérivés de la quinazoline, ainsi que des méthodes faisant appel à ces composés.
Harris G. Davis
Mcmahon Gerald
Tang Peng Cho
Osler Hoskin & Harcourt Llp
Sugen Inc.
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