C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/00 (2006.01) C12N 5/09 (2010.01) A61K 35/14 (2006.01) A61K 35/28 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/48 (2006.01) G01N 33/569 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2422162
The present invention relates to novel methods and compositions for detection and isolation of cancer cells with metastatic potential. The invention further relates to assays for measuring the metastatic potential of such cancer cells and drug screening assays for the identification of agents having anti- metastatic potential. The present invention further provides methods and compositions for inhibiting the metastatic potential of cancer cells by modulating the activity of serine integral membrane proteases [(SIMP) consisting of seprase and dipedidyl peptidase IV (DPPIV) ]expressed on the surface of metastasizing cancer cells.
La présente invention concerne de nouvelles méthodes et compositions destinées à la détection et à l'isolation de cellules cancéreuses pourvues d'un potentiel métastatique. Cette invention concerne aussi des dosages servant à mesurer le potentiel métastatique de telles cellules cancéreuses, et des dosages de criblage de médicaments servant à identifier des agents dotés d'un potentiel anti-métastatique. Cette invention a également trait à des méthodes et à des compositions d'inhibition du potentiel métastatique de cellules cancéreuses par modulation de l'activité des protéases de membrane intégrale à sérine comprenant la séprase et la dipétidyl peptidase IV (DPPIV) exprimées à la surface de cellules cancéreuses au cours du processus de métastase.
Gowling Lafleur Henderson Llp
The Research Foundation Of State University Of New York
LandOfFree
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