A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/44 (2006.01) A61K 31/00 (2006.01) A61K 31/4178 (2006.01) A61K 31/437 (2006.01) C12Q 1/00 (2006.01) G01N 33/48 (2006.01)
Patent
CA 2144047
This invention provides a method of and compositions for increasing or maintaining glomerular filtration rate while pre- serving renal structure in a patient comprising administering an angiotensin II type 1 vascular receptor antagonist to the patient, independent of its effects on systemic blood pressure. The invention provides that, by administering the AII type 1 receptor anta- gonist, blood flow to the kidney can be improved without sacrificing intraglomerular pressure and therefore glomerular filtration and that even with this enhanced glomerular pressure and filtration, renal structure is preserved. Also provided is a method of screening AII type 1 receptor antagonists for the ability to maintain or increase glomerular filtration rate while decreasing mesan- gial matrix accumulation comprising the steps of administering the antagonist in an animal model characterized by decreased glomerular filtration rate and increased mesangial matrix accumulation and selecting the compounds that increase glomerular fil- tration rate while decreasing mesangial matrix accumulation.
Fogo Agnes
Ichikawa Iekuni
Kon Valentina
Gowling Lafleur Henderson Llp
Vanderbilt University
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