Method and compositions for making acsf and acsf antagonists

Details Method and compositions for making acsf and acsf antagonists Method and compositions for making acsf and acsf antagonists

C - Chemistry, Metallurgy

12

N

167/44, 195/1.22

C12N 15/12 (2006.01) A61K 39/395 (2006.01) C07K 14/435 (2006.01) C07K 14/60 (2006.01) C07K 14/635 (2006.01) C07K 16/26 (2006.01) C12N 1/20 (2006.01) C12N 5/10 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01) G01N 33/74 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1341048

The complete amino acid and nucleotide sequence for adenylate cyclase stimulating factor is provided, thereby facilitating the synthesis of ACSF in recombinant cell culture. ACSF amino acid sequence variants and ACSF antibodies are provided which are useful in the treatment of humoral hypercalcemia of malignancy or in immunoassays for ACSF. In particular, antibodies capable of binding only the C-terminal domains of ACSF are useful in immunoassays for ACSF which avoid interference by parathyroid hormone. Also provided are novel polypeptides selected from the group of the ACSF basic peptide, the ACSF C-terminal peptide, or the ACSF domain containing both of the basic and C-terminal peptides.

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