C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/57 (2006.01) A61K 38/43 (2006.01) A61K 38/48 (2006.01) A61P 19/10 (2006.01) C07K 16/18 (2006.01) C12N 9/64 (2006.01) C12N 15/62 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2418461
The object of the present invention is to increase PHEX activity to improve the osteogenic process in a mammal where this process has been diminished due to pathology or a condition that require osteogenesis. Osteocalcin is an endogenous inhibitor of the PHEX activity. Therefore, the identification of a substance capable of potentiating PHEX activity by preventing the inhibitory action of endogenous inhibitors will improve osteogenesis. Since PHEX is generally associated with the growth plane of bone or teeth and the absence of osteocalcin is associated with increased bone mass, potentiation of PHEX activity can promote bone growth. Increased PHEX activity can also be obtained by administration of the enzyme itself.
L'invention concerne l'augmentation de l'activité du PHEX afin d'améliorer le processus ostéogénique chez un mammifère lorsque ledit processus diminue par suite de maladie ou de condition nécessitant l'ostéogenèse. L'ostéocalcine étant un inhibiteur de l'activité du PHEX, l'identification d'une substance susceptible de potentialiser cette activité par la prévention de l'action inhibitrice d'inhibiteurs endogènes améliorera donc l'ostéogenèse. Le PHEX étant d'ordinaire associé à la croissance des os ou des dents et l'absence de l'ostécalcine étant associée à une masse osseuse accrue, la potentialisation de l'activité du PHEX peut favoriser la croissance osseuse. On peut également obtenir une activité du PHEX accrue en administrant l'enzyme elle-même.
Biomep Inc.
Enobia Pharma Inc.
Goudreau Gage Dubuc
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