C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 411/04 (2006.01) C07D 327/04 (2006.01) C12P 41/00 (2006.01) C07H 13/02 (2006.01) C07H 19/06 (2006.01) C12P 19/38 (2006.01)
Patent
CA 2678778
The present invention relates to a method of preparing BCH-189 and various analogs of BCH-189 from inexpensive precursors with the option of introducing functionality as needed. This synthetic route allows the stereoselective preparation of the biologically active isomer of these compounds, .beta.-BCH-189 and related compounds. Furthermore, the steochemistry at the nucleoside 4' position can be controlled to produce enantiomerically--enriched .beta.-BCH-189 and its analogs.
Choi Woo-Baeg
Liotta Dennis C.
Emory University
Gowling Lafleur Henderson Llp
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