Method and compositions for the synthesis of dioxolane...

Details Method and compositions for the synthesis of dioxolane... Method and compositions for the synthesis of dioxolane...

C - Chemistry, Metallurgy

07

D

C07D 405/04 (2006.01) C07D 473/00 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2237730

The present invention relates to methods and compositions for preparing biologically important nucleoside analogues containing 1,3-dioxolane sugar rings. In particular, this invention relates to the stereoselective synthesis of the beta (cis) isomer by glycosylating the base with an intermediate of formula (II) below a temperature of about -10 ~C, wherein R1 and L are as defined herein.

L'invention concerne des procédés et des compositions pour préparer des analogues de nucléosides ayant des propriétés biologiques importantes, contenant comme sucre le groupe cyclique 1,3-dioxolanne. En particulier, cette invention concerne la synthèse stéréosélective du bêta (cis) isomère par la glycosylation de la base avec un intermédiaire de la formule (II), à une température inférieure à environ -10 ·C. Dans cette formule, R¿1? et L ont la signification donnée dans la description.

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