A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/505 (2006.01) A61K 31/519 (2006.01) A61P 25/22 (2006.01)
Patent
CA 2507609
A method for treating anxiety in a patient by orally administering to said patient a daily dose of the active ingredient, 2-pyridinyl[7-(4- pyridinyl)pyrazolo[1,5-a]~-pyrimidin-3-yl]-methanone or its pharmaceutically acceptable salts, especially Ocinaplonin, in two separate divided administrations, with the first portion being administered in a slow release form and the remaining portion being administered in instant release form so as to maintain the blood levels of this active ingredient at therapeutically relevant levels to keep the anti anxiety effect in the patient during the periods between administrations of this active ingredient as well as pharmaceutical compositions containing this active ingredient for administration in connection with the above method.
Méthode de traitement de l'anxiété consistant à administrer à un patient, par voie orale, une dose du principe actif, la 2-pyridinyl[7-(4-pyridinyl)pyrazolo[1,5-a]-pyrimidin-3-yl]-méthanone ou un de ses sels pharmaceutiquement acceptable, notamment l'ocinaplonine, en deux administrations séparées ; la première partie étant administrée sous une forme à libération retardée, et la partie restante sous une forme instantanée afin de maintenir les taux sanguins du principe actif à des niveaux thérapeutiques garantissant l'effet anti-anxiété entre les administrations du principe actif. L'invention concerne aussi des compositions pharmaceutiques contenant ce principe actif et destinées à être administrées dans le cadre de ladite méthode.
Beer Bernard
Codd Janet
Nascime Limited
Smart & Biggar
LandOfFree
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