C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 203/00 (2006.01) A61K 31/04 (2006.01) A61K 31/21 (2006.01) A61K 31/34 (2006.01)
Patent
CA 2208666
Pharmaceutical compositions in topical or parenteral form containing organic nitrites are effective in treating male impotence and erectile dysfunction through topical or intracavernosal administration to the penis. Methods of treatment utilizing the nitrite-containing compositions are also disclosed, as are certain novel organic nitrite compounds. The beneficial effects of such treatment can be demonstrated in rats by measuring cavernosal blood pressure and arterial blood pressure (as measured in the left femoral artery) following intracavernous injection of an organic nitrite and comparing those blood pressure readings to those obtained after intracavernous injection of a nitrate such as nitroglycerin.
Compositions pharmaceutiques pouvant s'administrer localement ou par voie parentérale, à teneur en azotites organiques et permettant de traiter efficacement l'impuissance masculine et le dysfonctionnement de l'érection par administration locale ou à travers les corps caverneux du pénis. L'invention concerne également des procédés de traitement utilisant ces compositions, ainsi que certains nouveaux composés d'azotites organiques. Les avantages de ce traitement peuvent être démontrés chez le rat au moyen de la mesure de la pression sanguine artérielle (prise dans l'artère fémorale gauche) suivant l'injection dans les corps caverneux d'azotite organique, ainsi qu'au moyen de la comparaison des résultats de la pression sanguine avec ceux ayant été obtenus après l'injection dans les corps caverneux d'un nitrate, tel que la nitroglycérine.
Bauer John Anthony
Fung Ho-Leung
Baker Norton Pharmaceuticals Inc.
Fetherstonhaugh & Co.
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