Method and compositions for treating late phase allergic...

A - Human Necessities – 61 – K

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A61K 31/727 (2006.01) A61K 9/12 (2006.01) A61K 9/72 (2006.01) A61P 11/06 (2006.01) A61P 29/00 (2006.01) A61P 37/08 (2006.01)

Patent

CA 2298445

A method of treating a mammalian patient suffering from or prone to a condition characterized by late phase allergic reactions, airway hyperresponsiveness or inflammatory reactions, e.g., asthma, allergic rhinitis, allergic dermatitis, allergic conjunctivitis, inflammatory bowel disease or rheumatoid arthritis, comprising the administration to the patient of an oral, parenteral, intrabronchial, topical, intranasal or intraocular pharmaceutical composition containing in each dose about 0.005 to about 1.0 mg per kilogram of patient body weight of ultra-low molecular weight heparins (ULMWH) or other sulfated polysaccharides having average molecular weights of about 1,000-3,000 daltons. Suitable inhalant and other pharmaceutical compositions for use in the novel treatment method are also disclosed.

L'invention concerne un procédé permettant de traiter un patient mammifère souffrant, ou prédisposé à souffrir, d'un trouble caractérisé par une hypersensibilité des voies aériennes, des réactions inflammatoires ou des réactions allergiques tardives, par exemple, l'asthme, la rhinite allergique, la dermatite allergique, la conjonctivite allergique, la maladie intestinale inflammatoire ou l'arthrite rhumatoïde. Ce procédé consiste à administrer au patient - par voie orale, parentérale, intrabronchique, topique, intranasale ou intraoculaire - une composition pharmaceutique renfermant dans chaque dose entre environ 0,005 et environ 1,0 mg par kilogramme de corps de patient d'héparines de très fiable poids moléculaire (ULMWH) ou d'autres polysaccharides sulfatés dont le poids moléculaire moyen est compris entre environ 1 000 et environ 3 000 daltons. L'invention se rapporte également à des compositions susceptibles d'être inhalées et à d'autres compositions pharmaceutiques destinées à être utilisées dans le cadre de ce nouveau procédé de traitement.

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