A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/00 (2006.01) A61K 31/185 (2006.01) A61K 31/366 (2006.01) A61K 31/551 (2006.01) A61P 11/00 (2006.01) A61P 11/06 (2006.01)
Patent
CA 2470442
The invention concerns compositions and methods for treating respiratory pathologies. The invention also concerns compositions and methods for regulating pulmonary epithelium paracellular permeability. The inventive compositions and methods are based in particular on the use of agents or conditions modulating the cytoskeleton tension, more particularly compounds inhibiting contraction of the light chain of pulmonary epithelial cell myosin, in particular enterocytes. The invention is useful for preventive or curative treatment of various pathologies, such as asthma, allergies, chronic obstructive lung diseases and the like in mammals, in particular humans.
La présente demande concerne des compositions et méthodes pour letraitement de pathologies respiratoires. Elle concerne également des compositions et méthodes permettant de réguler la perméabilité paracellulaire de l'épithélium pulmonaire. Les compositions et méthodes de l'invention reposent notamment sur l'utilisation d'agents ou de conditions modulant la tension du cytosquelette, plus particulièrement des composés inhibant la contraction de la chaîne légère de la myosine des cellules épithéliales pulmonaires, notamment des entérocytes. L'invention est utilisable pour le traitement préventif ou curatif de pathologies variées, telles que asthme, allergies, maladies obstructives, etc., chez les mammifères, notamment les humains.
Robic
Rytek
LandOfFree
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