A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/228, 167/233
A61K 31/44 (2006.01) A61K 31/135 (2006.01) A61K 31/34 (2006.01) A61K 31/38 (2006.01) A61K 31/40 (2006.01)
Patent
CA 1338508
This invention provides a method for treating the symptoms of parkinsonism which comprises administering to a human or other mammal surfering from the symptoms of parkinsonism an effective amount of a compound selected from the group consisting of optically-active or racemic compounds represented by the general formula: Image wherein R1 is selected from the group consisting of organic radicals methyl, substituted or unsubstituted phenyls, pyridyl, hydroxyphenyl, Image X is oxygen or sulfur, Y is selected from the group consist- ing of hydroxy, nitro, cyano, azido, amino, acylamino, carboxyamido, trifluoromethyl, sulfate, sulfonamido, halogen, hydrocarbyl and hetero atom-substituted hydrocarbyl radicals, wherein said heteroatoms are selected from the group consist- ing of halogen, nitrogen, oxygen, sulfur and phosphorus and said hydrocarbyl radicals comprise from 1 to 12 carbon atoms, and a is an integer of from zero to 3, R2, R3 and R4 are each selected from the group consisting of H and OA, A is H or is selected from the group consisting of hydrocarbyl radicals, Image , and Image R5 is selected from the group consisting of hydrocarbyl radicals; n is an integer between 1 and 3; and R6 is an alkyl chain having between 1 and 3 carbon atoms with the provision that at least one of R2, R3 and R4 is H, that at least one of R2, R3 and R4 is not H, and that R2 and R4 are not both OA, and pharmaceutically acceptable salts thereof. Preferably, R2 is OA. Preferably, R2 is OA and A is H, and the compound is the (-) isomer.
602454
Aderis Pharmaceuticals Inc.
Gowling Lafleur Henderson Llp
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