Method and compositions to screen compounds for enhancement...

Details Method and compositions to screen compounds for enhancement... Method and compositions to screen compounds for enhancement...

A - Human Necessities

61

K

A61K 39/395 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01) G01N 33/94 (2006.01)

Patent

CA 2076665

2076665 9113359 PCTABS00007 This invention is directed to a composition comprising a substantially purified protein which enhances endogenous stimulus-induced neurotransmitter release, said neurotransmitter being selected from the group consisting of acetylcholine, dopamine or serotonin, said protein having a binding affinity constant of at least 2.9 ± 0.8 nM for tritiated 3,3-bis(4-pyridinylmethyl)-1-phenylindolin-2-one as determined by a Scatchard analysis, and said protein being trypsin sensitive and phospholipase C insensitive.

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