Method and compound to reduce the incidence of diabetes in a...

Details Method and compound to reduce the incidence of diabetes in a... Method and compound to reduce the incidence of diabetes in a...

A - Human Necessities

61

K

A61K 31/401 (2006.01) A61K 31/138 (2006.01) A61K 31/40 (2006.01) A61K 31/403 (2006.01) A61K 31/41 (2006.01) A61K 31/4178 (2006.01) A61K 31/4184 (2006.01) A61K 31/472 (2006.01) A61K 38/55 (2006.01) A61K 45/06 (2006.01) A61P 3/10 (2006.01) A61P 9/04 (2006.01)

Patent

CA 2458288

The present invention relates to the effect of angiotensin-converting enzyme (ACE) inhibitors on the prevention of diabetes in a subject with left ventricular dysfunction. A retrospective study was conducted to assess the effect of the ACE inhibitor enalapril on the incidence of diabetes in a group of patients from the Montreal Heart Institute enrolled in the Studies of Left Ventricular Dysfunction (SOLVD). Clinical charts were evaluated for fasting plasma glucose (FPG) levels by blinded reviewers. A diagnosis of diabetes was made when a FPG >= 126 mg/dL (7 mmol/L) was found at 2 visits (follow-up, 2.9~1.0 years). Of the 291 non-diabetic patients enrolled in the SOLVD study, 153 of these were on enalapril and 138 were on placebo. Baseline characteristics were similar in the 2 groups. Forty patients developed diabetes during follow-up, 9 (5.9%) in the enalapril group and 31 (22.4%) in the placebo group (P<0.0001). By multivariate analysis, enalapril remained the most powerful predictor for risk reduction of developing diabetes (hazard ratio, 0.22; 95% confidence intervals, 0.10 to 0.46; P<0.0001 ). Enalapril therefore significantly reduces the incidence of diabetes in patients with left ventricular dysfunction, especially those with impaired FPG.

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