Method and compounds for aica riboside delivery and for...

Details Method and compounds for aica riboside delivery and for... Method and compounds for aica riboside delivery and for...

C - Chemistry, Metallurgy

07

H

167/202, 260/229

C07H 19/052 (2006.01) A61K 31/00 (2006.01) A61K 31/70 (2006.01)

Patent

CA 2008325

ABSTRACT OF THE DISCLOSURE AICA riboside and prodrugs of AICA riboside are provided which lower blood glucose for the treatment of various pathologic conditions, including hypoglycemia, insulin defi- ciency, insulin resistance diabetes and Syndrome X. Prodrugs of AICA riboside provide AICA riboside in an orally bioavailable form. The use of adenosine kinase inhibition and ZMP enhancement for lowering blood glucose are also described.

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