Method and compounds for modulating insulin production

Details Method and compounds for modulating insulin production Method and compounds for modulating insulin production

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 31/015 (2006.01) A61K 31/235 (2006.01) A61K 31/355 (2006.01) A61K 31/4453 (2006.01) A61K 31/46 (2006.01) A61K 31/4748 (2006.01) A61K 31/5415 (2006.01) A61K 31/573 (2006.01) A61P 3/10 (2006.01) C12N 15/85 (2006.01) C12Q 1/00 (2006.01) C12N 15/113 (2010.01) C12N 15/65 (2006.01)

Patent

CA 2703260

The present invention provides screening methods for the detection of agents that affect various aspects of .beta.-cell biology, particularly insulin gene expression. Screening methods are also provided for detection of agents that affect .beta.-cell differentiation from progenitor cells. Additionally, agents identified using such methods are provided and are useful for increasing insulin gene expression and reducing lipotoxicity.

L'invention concerne des procédés de criblage pour la détection d'agents qui affectent divers aspects de la biologique de cellule b, en particulier l'expression de gène d'insuline. Les procédés de criblage sont également prévus pour la détection d'agents qui affectent la différenciation de cellule b de cellules progénitrices. De plus, les agents identifiés en utilisant de tels procédés sont fournis et sont utiles pour augmenter l'expression de gène d'insuline et réduire la lipotoxicité.

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