Method and device for calculating dialysis efficiency

A - Human Necessities – 61 – M

Patent

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Details

A61M 1/14 (2006.01) A61B 5/145 (2006.01) A61M 1/16 (2006.01) G01N 33/487 (2006.01)

Patent

CA 2313209

Method and apparatus for calculating the concentration of a substance in blood of a mammal. Blood from the mammal is passed through a dialyser having a semipermeable membrane and a dialysing fluid is passed at the other side of the membrane. The concentration of urea c d is measurod in the dialysabe emitted from the dialyser and the dialysate fluid flow rate Q d. A disturbance is introduced in the dialyser whereupon the effective dialysance K e of the dialyser is calculated. Finally, the concentration of urea in blood is calculated by the formula c pw = c d × Q d/K e. By using the curve of urea concentration c d versus time in the dialysate, it is possible to calculate the initial mass m 0 of urea in the blood. Finally, the distribution volume V of urea in the body of said mammal is calculated according to the formula V = m 0/c pw.

L'invention concerne un procédé et un appareil permettant de calculer la concentration d'une substance dans le sang d'un mammifère. Le sang du mammifère passe par un dialyseur doté d'une membrane semi-perméable et un fluide de dialyse circule de l'autre côté de la membrane. La concentration d'urée cd dans le dialysat émanant du dialyseur et le débit Qd du fluide de dialyse sont calculés. Une perturbation est introduite dans le dialyseur. Ensuite la dialysance effective Ke du dialyseur est calculée. La concentration d'urée dans le sang est calculée d'après la formule cpw = cd x Qd/Ke. A l'aide de la courbe de la concentration d'urée cd vs temps dans le dialysat, on calcule la masse initiale m0 d'urée dans le sang. Enfin, le volume de distribution V d'urée dans l'organisme du mammifère concerné est calculée d'après la formule V = m0/cpw.

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