Method and device for determining the glucose concentration...

A - Human Necessities – 61 – B

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A61B 5/00 (2006.01)

Patent

CA 2607396

The invention relates to a method and a device for determining the glucose concentration in tissue liquid (40). Said method and device are used for detecting (sensor 12) measured values for glucose and an endogenous reference substance in a sample liquid (42) obtained by means of microdialysis, microperfusion, or ultrafiltration (probe 10) and correcting the glucose value in accordance with the measured value for the reference substance. The invention is characterized in that the glucose recovery rate is determined from a non-linear correlation with the recovery rate for the ionic reference substance while the measured value for glucose is corrected therewith. Furthermore, the lactate concentration and/or pyruvate concentration is/are used as (an) additional reference substance(s) in the sample liquid to make further corrections.

L'invention concerne un procédé et un dispositif servant à déterminer la concentration de glucose dans du liquide tissulaire (40). Des valeurs de mesure pour le glucose et pour une substance de référence endogène sont détectées (capteur 12) dans un échantillon liquide (42) obtenu par microdialyse, microperfusion ou ultrafiltration (sonde 10) et la valeur de glucose est corrigée en fonction de la valeur mesurée pour la substance de référence. Selon l'invention, le taux de récupération pour le glucose est déterminé à partir d'une relation non linéaire au taux de récupération pour la substance de référence ionique et la valeur de mesure de glucose est corrigée au moyen de ce taux, la concentration en lactate et/ou en pyruvate en tant qu'autre substance de référence dans l'échantillon liquide étant également utilisée pour parfaire la correction.

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