C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/077 (2010.01) C12N 5/10 (2006.01) C12N 7/01 (2006.01) C12N 15/86 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2472016
The invention concerns a method for identifying compounds capable of modulating adipocyte differentiation, which consists in contacting the compound to be tested with genetically modified pre-adipocyte cells overexpressing the <I>REV-ERB-ALPHA</I> receptor and measuring the adipocyte differentiation of said genetically modified cells with the adipocyte differentiation of same said genetically modified pre-adipocyte cells in the absence of said compound to be tested. The invention also concerns genetically modified pre-adipocyte cells overexpressing the <I>REV-ERB-ALPHA</I> receptor as well as the method for preparing said cells.
L'invention concerne une méthode d'identification de composés capables de moduler la différenciation adipocytaire, mettant en contact un composé à tester avec des cellules pré-adipocytaires génétiquement modifiées sur-exprimant le récepteur REV-ERB ALPHA et mesurant la différenciation adipocytaire desdites cellules génétiquement modifiées par rapport à la différenciation adipocytaire des mêmes dites cellules pré-adipocytaires génétiquement modifiées en l'absence dudit composé à tester. Elle concerne aussi des cellules pré-adipocytaires génétiquement modifiées sur-exprimant le récepteur REV-ERB ALPHA ainsi que le procédé de préparation desdites cellules.
Genfit
Robic
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