G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 21/77 (2006.01) G01N 21/55 (2006.01) G01N 21/64 (2006.01)
Patent
CA 2335438
Total internal reflection fluorescence is used for imaging biopolymer arrays. A beam of light (2) is guided into the solid support (1) at a certain angle, evoking total internal reflection in the solid support. A certain portion of light will not reflect from the inner glass surface but penetrate out of the glass as an evanescent wave. It will excite fluorophores incorporated in the biopolymer molecules, contiguously attached to the surface of the support. Fluorescence thus evoked will be guided to a light sensitive element (7), providing data on the fluorescent molecules attached to the surface of the support. The said detection of fluorescence signals is rapid, taking about 10 seconds per fluorescence channel.
La fluorescence de la réflexion totale interne est utilisée pour l'imagerie de jeux ordonnés d'échantillons de biopolymères. Un faisceau de lumière (2) est dirigé à l'intérieur d'un support solide (1) à un certain angle, provoquant une réflexion totale interne dans le support solide. Une certaine partie de la lumière ne sera pas reflétée à partir de la surface de verre interne mais va sortir hors du verre sous la forme d'une onde évanescente. Elle va exciter les fluorophores incorporées dans les molécules de biopolymère, fixées de manière adjacente à la surface du support. La fluorescence ainsi provoquée va être dirigée vers un élément photosensible (7), fournissant des données concernant les molécules fluorescentes fixées à la surface du support. Ladite détection de signaux de fluorescence est rapide, parcourant en dix secondes environ chaque canal de fluorescence.
Berik Jevgeni
Kurg Ants
Metspalu Andres
Asper Ou
Kirby Eades Gale Baker
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