Method and device for mixing liquids

Details Method and device for mixing liquids Method and device for mixing liquids

G - Physics

01

N

G01N 1/38 (2006.01) B01F 11/00 (2006.01) B01F 13/00 (2006.01) B01F 13/08 (2006.01) B01L 3/00 (2006.01) G01J 1/02 (2006.01) G01J 1/04 (2006.01) G01J 1/42 (2006.01) G01N 1/10 (2006.01) G01N 21/84 (2006.01) G01N 21/86 (2006.01) G01N 21/88 (2006.01) B01F 15/02 (2006.01) G01N 35/00 (2006.01)

Patent

CA 2192936

The present invention provides methods and apparatus for mixing two or more liquids. The method comprises forming a liquid droplet (14), containing two or more liquids on a substantially planar surface (12) in containerless containment on the surface and causing the droplet to deform in an essentially zero air flow environment thereby mixing the liquids. An apparatus of the invention comprises a) a substantially planar support (12), b) means (22, 24) for dispensing liquids onto the support to form a droplet, and c) non- evaporative means for causing the droplet to deform without deforming the support thereby mixing the liquids. The drop can be deformed by, for example, application of acoustic energy or a variable electrostatic field. The methods and apparatus have particular application to the determination of an analyte.

La présente invention concerne des procédés et un appareil pour mélanger au moins deux liquides. Ce procédé consiste à former une gouttelette (14) de liquide contenant au moins deux liquides sur une surface sensiblement plane (12), en confinement sans récipient sur la surface, et à provoquer la déformation de cette gouttelette dans un milieu avec un écoulement d'air sensiblement nul, pour ainsi mélanger les liquides. Un appareil selon la présente invention comporte a) un support sensiblement plane (12), b) des moyens (22, 24) pour distribuer des liquides sur le support en vue de former une gouttelette, et c) des moyens non évaporatifs pour provoquer la déformation de la gouttelette sans déformation du support, pour ainsi mélanger les liquides. La gouttelette peut être déformée par exemple par application d'énergie accoustique ou d'un champ électrostatique variable. Les procédés et l'appareil décrits s'utilisent notamment pour la détermination d'un analyte.

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