C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/071 (2010.01) A61K 35/407 (2006.01) A61K 38/18 (2006.01) A61K 38/22 (2006.01) A61K 38/31 (2006.01) C12N 5/00 (2006.01)
Patent
CA 2495395
The invention relates to an in-vitro and in-vivo method for multiplying and differentiating cells, during which the growth process of the cells is initiated or terminated and structurally directed by the use of growth factors thrombopoietin (TPO) and/or erythropoietin (EPO), and/or growth hormone (GH), particularly human growth hormone (HGH), and/or somatostatin and/or leukemia inhibitory factor (LIF) and/or ciliary neurotropic factor (CNTF). The invention also relates to a biological matrix or supporting structure containing the aforementioned growth factors, and to a method and device for the production thereof and for carrying out the inventive method.
La présente invention concerne d'une part un procédé in vitro et in vivo de multiplication et de différenciation de cellules, selon lequel le processus de croissance des cellules est induit ou stoppé et structurellement orienté par l'utilisation des facteurs de croissance que sont la thrombopoïétine (TPO) et / ou l'érythropoïétine (EPO), et / ou l'hormone de croissance (GH), en particulier l'hormone de croissance humaine (HGH), et / ou la somatostatine et / ou le facteur d'inhibition de la leucémie (LIF) et / ou le facteur neurotrophique ciliaire (CNTF). Elle concerne d'autre part une matrice ou une structure de support biologique contenant les facteurs de croissance cités, ainsi qu'un procédé et un dispositif de production de ladite matrice ou structure en vue de la mise en oeuvre dudit procédé.
Bader Augustinus
Bionethos Holding Gmbh
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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