Method and device for non-invasive prenatal diagnosis

Details Method and device for non-invasive prenatal diagnosis Method and device for non-invasive prenatal diagnosis

C - Chemistry, Metallurgy

12

Q

C12Q 1/24 (2006.01) C12N 5/071 (2010.01) C12M 3/00 (2006.01) C12Q 1/68 (2006.01) G01N 15/10 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2686338

Method for non- invasive prenatal diagnosis comprising the following steps: a. obtain a sample of an organic fluid having a high probability of containing foetal cells from a pregnant woman; b. enrich said sample of organic fluid in at least one population of cells comprising at least one type of foetal nucleated cells; c. isolate at least one cell from among said at least one type of foetal nucleated cells; d. perform a genetic analysis on said at least one cell isolated from among said at least one type of foetal nucleated cells in order to highlight at least one genetic characteristic of said at least one foetal nucleated cell suitable for permitting said diagnosis; wherein the step of isolating at least one cell from among said at least one type of foetal nucleated cells is performed by individually selecting single cells in a microfluidic device designed for said purpose.

L'invention concerne un procédé de diagnostic prénatal non invasif comprenant les étapes suivantes : a. obtenir un échantillon d'un fluide organique ayant une probabilité élevée de contenir des cellules fAEtales provenant d'une femme enceinte; b. enrichir ledit échantillon de fluide organique en au moins une population de cellules comprenant au moins un type de cellules nucléées fAEtales; c. isoler au moins une cellule parmi ledit ou lesdits types de cellules nucléées fAEtales; d. effectuer une analyse génétique sur ladite ou lesdites cellules isolées parmi ledit ou lesdits types de cellules nucléées fAEtales afin de mettre en évidence au moins une caractéristique génétique de ladite ou desdites cellules nucléées fAEtales appropriée pour permettre ledit diagnostic; l'étape d'isolement d'au moins une cellule parmi ledit ou lesdits types de cellules nucléées fAEtales étant effectuée par la sélection individuelle de cellules uniques dans un dispositif microfluide mis au point à cette fin.

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