Method and device for pcr-amplification and detection of...

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/68 (2006.01) C12M 1/38 (2006.01) C40B 30/04 (2006.01) C40B 40/06 (2006.01) C40B 60/12 (2006.01)

Patent

CA 2510721

The invention relates to a DNA-Chip comprising a flat carrier and an array of spots containing probe molecules (oligonucleotides) which are arranged on said carrier. Each spot is associated with a microelectrode arrangement for impedance spectroscopic detection of binding events occurring between the probe molecules and target molecules (DNA fragments) applied by means of an analyte solution. In order to increase the sensitivity or the binding specific measuring effects of the biochip, the electrode arrangement is at least partially embedded in a hydrophilic reaction layer containing probe molecules and which is permeable to target molecules.

L'invention concerne une puce à ADN qui comporte un support plat ainsi qu'un réseau de spots contenant des molécules sondes (oligonucléotides), placé sur ledit support. Un réseau de microélectrodes, servant à la détection, par spectroscopie d'impédance, d'événements de liaison entre les molécules sondes et des molécules cibles (fragment d'ADN) appliquées au moyen d'une solution d'analyte, est affecté à chaque spot. L'objectif de l'invention est d'accroître la sensibilité ou l'effet de mesure, spécifique des liaisons, de la biopuce. A cet effet, le réseau d'électrodes est incorporé au moins partiellement dans une couche de réaction hydrophile contenant des molécules sondes et perméable aux molécules cibles.

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