Method and device for producing shaped microbial cellulose...

C - Chemistry – Metallurgy – 12 – P

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C12P 19/04 (2006.01) A61L 17/00 (2006.01) A61L 27/20 (2006.01) A61L 29/04 (2006.01) C08L 1/02 (2006.01)

Patent

CA 2400372

The use of exogenic materials for replacing blood vessels carries the risk of thrombosis and is therefore particularly unsuitable for microsurgical applications (inner vessel diameters of 1-3 mm and less), or only suitable under certain conditions. Replacements of blood vessels with a very small lumen in particular require biomaterials which guarantee that the surfaces of the prosthesis that come into contact with the blood are of a very high quality, and which reliably avoid this kind of thrombosis adhesion. The biomaterial is produced by immersing shaped body walls, especially of a glass matrix consisting of a glass tube and glass body, in a container of an inoculated nutrient solution so that the inoculated nutrient solution is drawn into the area between the walls of the shaped body and cultivation takes place in a moist, aerobic environment. In each subsequent cultivation process, an unused shaped body (glass body) is used as the shaped body wall for shaping the surface of the prosthesis material that is to come into contact with the blood when the biomaterial is used. This is the only sure way of reproducing the high surface quality of the vessel prosthesis and hereby reliably preventing thrombosis adhesion on the biomaterial used. The inventive method is particularly suitable for microsurgical applications, especially for replacing blood vessels and other internal hollow organs or as a cuff for covering nerve fibres, etc.

L'utilisation de matériaux étrangers à l'organisme comme des prothèses de vaisseaux sanguins comporte le risque de thrombose et est notamment peu ou pas adaptée aux applications microchirurgicales (diamètre interne de vaisseau 1 à 3 mm maximum). Pour remplacer précisément des vaisseaux sanguins de petits calibres, on a besoin de biomatériaux qui garantissent une très grande qualité des surfaces de prothèses en contact avec le sang et qui empêchent en toute fiabilité l'adhésion de caillots. Pour fabriquer le biomatériau, les parois du corps moulé, notamment d'une matrice de verre composée d'un tube de verre et d'un corps de verre, émergent dans un vaisseau contenant un bouillon de culture inoculé de telle façon que le bouillon de culture inoculé remonte dans l'espace entre les parois du corps moulé. La culture se trouve alors dans un milieu humide aérobie. Dans chaque procédé de culture, on utilise respectivement un corps moulé tout neuf (corps en verre) comme paroi de corps moulé pour former la surface de matériau de prothèse entrant en contact sanguin en cas d'utilisation du biomatériau. Ainsi seulement on peut obtenir une grande qualité de surface reproductible de la prothèse de vaisseau, ce qui supprime de façon sûre le risque d'adhésion de caillots sur le biomatériau utilisé. Ce procédé est particulièrement adapté aux applications de microchirurgie, par exemple, comme prothèse de vaisseau sanguin et autres organes creux internes ou comme manchette pour envelopper notamment les fibres nerveuses.

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

Method and device for producing shaped microbial cellulose... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method and device for producing shaped microbial cellulose..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method and device for producing shaped microbial cellulose... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-1664126

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.