A - Human Necessities – 61 – B
Patent
A - Human Necessities
61
B
A61B 3/12 (2006.01) A61B 5/00 (2006.01)
Patent
CA 2519218
The invention relates to a method of mapping the intraretinal pH of a retina which is marked by a pH-dependent fluorescent marker, in which the retina is illuminated with a first excitation radiation. According to the invention, a first image of the fluorescence emitted by the retina is formed as a bi-directional matrix of pixels at the wavelength of the peak of the fluorescence emission spectrum. Subsequently, the retina is illuminated with a second excitation radiation and a second image is formed of the fluorescence emitted thereby. Finally, the ratio at each pixel between the levels of fluorescence emitted in response to the two respective wavelengths is calculated, said ratio being representative of the pH of the retina, and a pH map of the retina is deduced.
Procédé de cartographie du pH intra-rétinien d'une rétine marquée par un marqueur fluorescent dépendant du pH, dans lequel on éclaire la rétine avec un premier rayonnement d'excitation. On forme une première image de la fluorescence émise par la rétine, sous forme d'une matrice bidirectionnelle de pixels, à la longueur d'onde du pic du spectre d'émission de fluorescence. Puis on éclaire la rétine avec un second rayonnement d'excitation. On forme une seconde image de la fluorescence émise par la rétine. Et on calcule le rapport en chaque pixel, représentatif du pH de la rétine, entre les niveaux de fluorescence émise en réponse aux deux longueurs d'onde d'excitation respectives, ce rapport étant, et on en déduit une carte du pH de la rétine.
Mordon Serge
Rochon Philippe
Centre Hospitalier Regional Et Universitaire de Lille (chru)
Goudreau Gage Dubuc
Institut National de La Sante Et de La Recherche Medicale (inser
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