Method and formulation for transdermal delivery of...

H - Electricity – 04 – N

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H04N 7/18 (2006.01)

Patent

CA 2566759

A method for formulating an immunologically active agent and an apparatus for delivery same, the method comprising the steps of providing a bulk immunologically active agent, subjecting the bulk immunologically active agent to tangential-flow filtration to provide an immunologically active agent solution, adding at least one excipient to the agent solution and spray-drying the agent solution to form an immunologically active agent product; the apparatus comprising a microprojection member that includes a plurality of microprojections having a biocompatible coating disposed thereon that includes a spray-dried immunologically active agent. In a preferred embodiment, the immunologically active agent comprises an influenza vaccine, more preferably, a split-varion influenza vaccine.

L'invention concerne une méthode permettant de formuler un agent actif sur le plan immunologique et un appareil permettant d'administrer ledit agent. Cette méthode consiste à produire un agent actif sur le plan immunologique en vrac, à soumettre cet agent actif sur le plan immunologique à une filtration tangentielle afin d'obtenir une solution à base d'agent actif sur le plan immunologique, à ajouter au moins un excipient à cette solution et à sécher par atomisation cette solution à base d'agent afin de former un produit à base d'agent actif sur le plan immunologique. Cet appareil comprend un élément de microprojection comportant une pluralité de microprojections recouvertes d'un revêtement biocompatible qui contient un agent actif sur le plan immunologique séché par atomisation. Dans un mode de réalisation préféré, cet agent actif sur le plan immunologique contient un vaccin antigrippal, de préférence, un vaccin antigrippal à constituants purifiés.

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