Method and formulation for treating vascular disease

Details Method and formulation for treating vascular disease Method and formulation for treating vascular disease

A - Human Necessities

61

K

A61K 31/22 (2006.01) A61K 31/198 (2006.01) A61K 31/366 (2006.01) A61K 31/405 (2006.01) A61K 31/41 (2006.01) A61K 31/4433 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2286671

A therapeutic mixture comprised of L-arginine and inhibitors of Hmg-CoA- Reductase is disclosed for the treatment of diseases related to endothelial dysfunction, wherein the endothelial dysfunction is relieved by stimulating the constitutive form of nitric oxide synthase (cNOS) to produce native nitric oxide (NO). The figure shows a schematic representation of the proposed NOS activation pathway

L'invention concerne un mélange thérapeutique constitué de L-arginine et d'inhibiteurs de la Hmg-CoA-Réductase, pour le traitement de maladies associées à un dysfonctionnement endothélial, que l'on fait disparaître par la stimulation de la forme constitutive du monoxyde d'azote synthétase (cNOS) de sorte que de l'oxyde nitrique natif (NO) soit produit.

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