Method and formulation of stimulating nitric oxide synthesis

A - Human Necessities – 61 – K

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A61K 45/06 (2006.01) A61K 31/04 (2006.01) A61K 31/195 (2006.01) A61K 31/21 (2006.01) A61K 31/50 (2006.01)

Patent

CA 2201784

A therapeutic mixture comprising a mixture of L-arginine and an agonist of nitric oxide synthase, namely nitroglycerin, is disclosed for the treatment of diseases related to vasoconstriction, wherein the vasoconstriction is relieved by stimulating the constitutive form of nitric oxide synthase (cNOS) to produce native nitric oxide (NO). The native NO having superior beneficial effect when compared to exogenous NO produced by an L-arginine independent pathway in terms of the ability to reduce clinical endpoints and mortality.

Cette invention se rapporte à un mélange thérapeutique constitué de L-arginine et d'un agoniste de la monoxyde d'azote synthétase, à savoir la nitroglycérine, ce mélange pouvant servir à traiter les maladies liées à une vasoconstriction, cette vasoconstriction étant soulagée par stimulation de la forme constitutive de la monoxyde d'azote synthétase (cNOS), afin de produire de l'oxyde d'azote natif (NO). Par rapport à l'oxyde d'azote exogène produit par une voie indépendante de la L-arginine, le NO natif possède des effets bénéfiques supérieurs quant à sa capacité de réduire les cas de traitement clinique arrivant en phase terminale et les cas de mortalité.

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