Method and kit for detecting a risk of acute myocardial...

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/68 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2584878

Genes, SNP markers and haplotypes of susceptibility or predisposition to CHD such as AMI are disclosed. Methods for diagnosis, prediction of clinical course and efficacy of treatments for AMI using polymorphisms in the AMI risk genes are also disclosed. The genes, gene products and agents of the invention are also useful for monitoring the effectiveness of prevention and treatment of AMI and CHD. Kits are also provided for the diagnosis, selecting treatment and assessing prognosis of CHD and AMI.

L'invention concerne des gènes, des marqueurs SNP et des haplotypes présentant une sensibilité ou une prédisposition à la maladie coronarienne, et notamment à l'infarctus aigu du myocarde. L'invention concerne également des procédés pour le diagnostic et la prévision de l'évolution clinique et de l'efficacité de traitements pour l'infarctus aigu du myocarde, au moyen de polymorphismes dans les gènes associés à un risque d'infarctus aigu du myocarde. Les gènes, produits génétiques et agents de cette invention sont également utiles pour surveiller l'efficacité de la prévention et du traitement de l'infarctus aigu du myocarde et de la maladie coronarienne. Des kits destinés au diagnostic, au choix du traitement et à l'évaluation du pronostic de la maladie coronarienne et de l'infarctus aigu du myocarde sont également fournis.

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