Method and kit for pyridinium crosslink assay

Details Method and kit for pyridinium crosslink assay Method and kit for pyridinium crosslink assay

C - Chemistry, Metallurgy

07

K

C07K 16/44 (2006.01) A61K 39/39 (2006.01) C07K 14/435 (2006.01) C07K 14/795 (2006.01) G01N 33/53 (2006.01) G01N 33/543 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2140921

A method of assaying bone collagen degradation activity in a human subject. In the method, a human urine sample is reacted with a monoclonal antibody which (i) is capable of reacting immunospecif- ically with pyridinium crosslinks selected from the group consisting of native free pyridinoline and native free deoxypyridinoline, and (ii) has a ratio of reactivity toward the selected pyridinium crosslinks and uri- nary pyridinium peptides larger than 1,000 daltons in molecular weight, of greater than about 5:1. An immunocomplex forms between the antibody reagent and the selected pyridinium crosslinks which are present in the sample, and the amount of immunocomplex is mea- sured. Also disclosed are antibody reagents and kits which can be used in the method.

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