Method and kit for the preparation of radiopharmaceuticals

C - Chemistry – Metallurgy – 01 – G

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C01G 19/00 (2006.01) A61K 51/04 (2006.01) A61K 51/12 (2006.01) C01C 3/12 (2006.01)

Patent

CA 1108049

ABSTRACT A method of preparing radiopharmaceuticals with the isotope technetium-99m, characterized in that (a) an aqueous solution of the chemical substance to be labelled, (b) the amount of pertechnetate calculated for the labelling and (c) an aqueous suspension of tin(II)-iron cyanide of the formula Sn2Fe(CN)6 resp. Sn3[Fe(CN)6]2 or of tin(II)-sulfide or tin(II)-telluride are mixed together in an amount, which - in respect of the reduction of the pertechnetate ions with lower valency - represents an excess, the mixing being carried out in such a way that the pertechnetate (b) or the suspension (c) is added last, the two-phase system obtained is kept in suspension and, after completion of the reduction of the pertechnetate, the solid phase is separated from the solution containing the chemical substance labelled with technetium- 99m. This method had the advantage that a minimal amount of insoluble tin-containing material is carried over into the labelled solution.

310893

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