Method and kit for use in the differentiation of ibd and ibs...

G - Physics – 01 – N

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G01N 33/68 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2747253

A quantification of the expression levels of a number of specific genes and their corresponding proteins can be utilized in accurately determining, using samples from faeces or blood, whether the patient is suffering from irritable bowel syndrome (IBS) or inflammatory bowel disease (IBD), and in a follow up analysis using a biopsy, determine if the same patient is afflicted with ulcerative colitis (UC) or Crohn's disease (CD). The method also has utility in determining the severity of the disease, as well as observing a patient's response to treatment.

L'invention concerne une quantification des niveaux d'expression d'un certain nombre de gènes spécifiques et leurs protéines correspondantes peuvent être utilisées pour déterminer avec précision, au moyen d'échantillons provenant de selles ou de sang, si le patient souffre d'un syndrome du côlon irritable (IBS) ou d'une maladie intestinale inflammatoire (IBD) et, dans une analyse de suivi utilisant une biopsie, pour déterminer si le même patient est atteint de recto-colite ulcéro-hémorragique (UC) ou de la maladie de Crohn (CD). Le procédé permet également de déterminer la gravité de la maladie, ainsi que d'observer la réaction d'un patient à un traitement.

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