Method and materials for sensitizing neoplastic tissue to...

Details Method and materials for sensitizing neoplastic tissue to... Method and materials for sensitizing neoplastic tissue to...

C - Chemistry, Metallurgy

07

H

167/202, 260/229

C07H 19/067 (2006.01) A61K 31/70 (2006.01)

Patent

CA 1269658

ABSTRACT Tumours are sensitized to radiation by administration of 5-chlorodeoxycytidine (5-CldC) or 5-halo-2'-halo-2'-deoxycyti- dine or uridine derivatives. Tetrahydrouridine (H4U) and/or 2'-deoxytetrahydrouridine (dH4U) is preferably coadministered with the deoxycytidine derivatives to inhibit deamination of the deoxycytidine derivatives. Optional prior concurrent treatment with agents to reduce the amount of competing metabolites to favor CldC , such as 5-fluorodeoxyuridne, results in a procedure that significantly increases the dose effects of X-radiation. Pharmaceutical compositions suitable for the sensitization of tumors to radiation are also disclosed, as are novel compounds.

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