Method and materials for use in diagnosing viral myocarditis

Details Method and materials for use in diagnosing viral myocarditis Method and materials for use in diagnosing viral myocarditis

A - Human Necessities

61

K

A61K 49/00 (2006.01)

Patent

CA 2560848

The invention consists of assay methods, assay kits and antibodies for detecting the polypeptide fragments of dystrophin protein cleavage by enteroviral protease 2A as a result of an enteroviral infection in the heart. The presence of dystrophin cleavage products in the myocytes or blood of a subject is diagnostic for enteroviral infection and myocarditis resulting therefrom.

Cette invention concerne des méthodes de dosage, des trousses de dosage ainsi que des anticorps permettant de détecter les fragments polypeptidiques du clivage de la protéine dystrophine par la protéase entérovirale 2A résultant d'une infection entérovirale dans le coeur. La présence de produits du clivage de la dystrophine dans les myocytes ou dans le sang d'un sujet révèle la présence d'une infection entérovirale et de la myocardite qui en résulte.

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