Method and means for detecting gluten-induced diseases

Details Method and means for detecting gluten-induced diseases Method and means for detecting gluten-induced diseases

G - Physics

01

N

G01N 33/564 (2006.01) G01N 33/573 (2006.01)

Patent

CA 2445102

The invention is directed to a method of detecting gluten-induced diseases such as e.g. celiac disease and dermatitis herpetiformis. Said diseases are indicated by the presence of autoantibodies against tissue transglutaminase tTG in the blood. The test is carried out on a whole blood sample using tTG liberated from the red blood cells of the blood sample as an autoantigen. The liberated autoantigens react with the autoantibodies in the sample and form antigen-antibody complexes, which are detected. The presence of such complexes indicates the disease. The invention is also directed to the use of the autoantigen in a test and to a test-kit.

La présente invention concerne une méthode de détection des maladies provoquées par le gluten telles que par exemple l'entéropathie au gluten et la dermatite herpétiforme. Ces maladies sont marquées par la présence dans le sang d'autoanticorps dirigés contre la transglutaminase tissulaire (tTG). Le test est pratiqué sur un échantillon de sang entier, la tTG libérée par les érythrocytes de l'échantillon de sang faisant office d'autoantigène. Les autoantigènes libérés réagissent avec les autoanticorps de l'échantillon et forment des complexes antigène-anticorps, qui sont détectés. La présence de tels complexes indique la maladie. Cette invention concerne également l'utilisation de l'autoantigène dans un test et une trousse de test.

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