C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/49 (2006.01) C07K 14/16 (2006.01) C12N 5/10 (2006.01) C12N 15/64 (2006.01) C12N 15/86 (2006.01) C12N 15/867 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2314609
Lentiviral vectors modified at the 5' LTR or both the 5' and 3' LTR's are useful in the production of recombinant lentivirus vectors. Such vectors can be produced in the absence of a functional tat gene. Multiple transformation of the host cell with the vector carrying the transgene enhances virus production.
L'invention porte sur des vecteurs lentiviraux modifiés en LRT 5', ou 5' et 3' servant à produire des vecteurs lentiviraux de recombinaison. Lesdits vecteurs peuvent être produits en l'absence du gène fonctionnel tat. De multiples transformations de la cellule hôte avec le vecteur porteur du transgène renforcent la production des virus.
Dull Thomas
Farson Deborah A.
Naldini Luigi
Witt Rochelle
Cell Genesys Inc.
Gbp Ip Llc
Gowling Lafleur Henderson Llp
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