A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61M 1/36 (2006.01) A61P 1/04 (2006.01)
Patent
CA 2651883
A method of treating inflammatory bowel disease (IBD) comprises providing an intestinal biopsy sample obtained from inflamed tissue of a patient; mechanically treating the sample to obtain a cell suspension; identifying cell surface markers of activated leukocytes selected from T lymphocytes, neutrophil granulocytes, and eosinophil granulocytes in the suspension; raising antibodies against one of more of the activated cells and immobilizing them on a support; providing a column loaded with the support; diverting a portion of the patient's peripheral blood to make it pass through the column before re-infusing it to the patient to make the activated leukocytes couple with antibodies on the support, thereby eliminating them from the blood stream. Also disclosed are corresponding columns and supports, and their use in the method.
Un procédé de traitement des maladies inflammatoires chroniques de l'intestin (MICI) comprend les étapes consistant à fournir un échantillon de biopsie intestinale prélevé sur le tissu enflammé d'un patient ; traiter mécaniquement l'échantillon pour obtenir une suspension cellulaire ; identifier des marqueurs antigéniques de leucocytes activés choisis parmi des lymphocytes T, des granulocytes neutrophiles, et des granulocytes éosinophiles dans la suspension ; générer des anticorps contre une ou plusieurs des cellules activées et les immobiliser sur un support ; prévoir une colonne chargée avec le support ; dévier une partie du sang périphérique du patient pour le faire passer sur la colonne avant de le re-transfuser dans le corps du patient pour que les leucocytes activés se couplent aux anticorps présents sur le support, les éliminant ainsi de la circulation sanguine. L'invention divulgue également les colonnes et supports correspondants, et leur utilisation dans le procédé.
Thorn Magnus
Winqvist Ola
Ibd Column Therapies International Ab
Ith Immune Therapy Holdings Ab
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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