C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01)
Patent
CA 2455161
The present invention relates to chemically modified genomic sequences, oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to methods for ascertaining genetic and/or epigenetic parameters of genes for use in the characterisation, grading, staging, and/or diagnosis of colon cancer, or the predisposition to colon cancer.
L'invention se rapporte à des séquences de génomes modifiées chimiquement, à des oligonucléotides et/ou à des oligopolymères PNA permettant de détecter la méthylation de cytosine d'ADN génomique, et à des procédés d'identification de paramètres génétiques et/ou épignénétiques de gènes à utiliser dans la caractérisation, l'histopronostic, la stadification et/ou le diagnostic du cancer du colon, ou la prédisposition au cancer du colon.
Distler Juergen
Model Fabian
Taubert Heike
Epigenomics Ag
Macrae & Co.
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