C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01)
Patent
CA 2549852
The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for predicting the disease free survival and/or response of a subject with a cell prolif~erative disorder of the breast tissues, to endocrine treatment.
L'invention se rapporte à des séquences génomiques et modifiées, à des oligonucléotides et/ou des oligomères PNA qui permettent de détecter l'état de méthylation de la cytosine de l'ADN génomique, et à un procédé qui permet de prédire la survie sans récidive et/ou la réponse d'un sujet souffrant d'un trouble de prolifération cellulaire des tissus mammaires à un traitement endocrinien.
Adorjan Peter
Dietrich Dimo
Foekens John
Harbeck Nadia
Hartmann Oliver
Epigenomics Ag
Heenan Blaikie Llp
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