C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/54 (2006.01) A61K 31/70 (2006.01) A61K 38/00 (2006.01) A61K 38/17 (2006.01) C07H 21/00 (2006.01) C07H 21/04 (2006.01) C07K 14/00 (2006.01) C12N 9/12 (2006.01) C12N 15/00 (2006.01) C12N 15/09 (2006.01) C12Q 1/00 (2006.01) C12Q 1/48 (2006.01) C12Q 1/68 (2006.01) G01N 33/573 (2006.01) A61K 35/76 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2186526
The present invention relates to isolated MEKK proteins, nucleic acid molecules having sequences that encode such proteins, and antibodies raised against such proteins. The present invention also includes methods to use such proteins to regulate signal transduction in a cell. The present invention also includes therapeutic compositions comprising such proteins or nucleic acid molecules that encode such proteins and their use to treat animals having medical disorders including cancer, inflammation, neurological disorders, autoimmune diseases, allergic reactions, and hormone-related diseases. When MEKK is expressed, it phosphorylates and activates MEKs including MEK-1, MEK-2 and JEK.
L'invention concerne des protéines MEKK isolées, des molécules d'acides nucléiques ayant des séquences qui codent de telles protéines, ainsi que des anticorpss dressés contre de telles protéines. La présente invention concerne également des procédés d'utilisation de telles protéines pour la régulation de la transduction de signaux dans une cellule. La présente invention concerne également des compositions thérapeutiques comprenant ces protéines ou des molécules d'acide nucléique qui codent ces protéines ainsi que leur utilisation pour le traitement d'animaux présentant des problèmes d'ordre médical tel qu'un cancer, une inflammation, des dysfonctionnements neurologiques, des maladies auto-immunes, des réactions allergiques et des maladies hormonales. Lorsque MEKK est exprimée, elle se phosphorylise et active les MEKs y compris MEK-1, MEK-2 et JEK.
Borden Ladner Gervais Llp
National Jewish Center For Immunology And Respiratory Medicine
LandOfFree
Method and product for regulating cell responsiveness to... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method and product for regulating cell responsiveness to..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method and product for regulating cell responsiveness to... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1439375