Method and product of gene transfer into cells

Details Method and product of gene transfer into cells Method and product of gene transfer into cells

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) A61K 35/28 (2006.01) A61K 48/00 (2006.01) C12N 5/02 (2006.01) C12N 5/10 (2006.01) C12N 15/87 (2006.01)

Patent

CA 2086844

- 38 - ABSTRACT A method of effecting transfer of a gene into mammalian cells, particularly, hematopoietic cells with a gene transfer vehicle, particularly a retroviral vector. The method comprises establishing a long term cell culture and exposing the culture to multiple, periodic infections of the vector containing the gene and, preferably, comprising multiple, periodic partial substitutions of the medium and cells. Genetically marked cells are returned to autologous recipients in the absence of any type of conditioning. The method provides improved gene transfer efficiency without increased toxicity.

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