C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
167/37
C12N 7/06 (2006.01) G01N 33/543 (2006.01) G01N 33/569 (2006.01)
Patent
CA 1245979
METHOD AND PRODUCTS FOR DETECTION OF HUMAN T CELL LEUKEMIA VIRUS Abstract of the Disclosure A first glycoprotein having a molecular weight of approximately 61,000-68,000 daltons in the MJ, C5-MJ, C91 PL or HUT-102 cell lines, of which 46,000 to 48,000 is the unglycosylated moiety, is obtained from cells infected with human T cell leukemia virus. A second glycoprotein having a molecular weight of approximately 45,000 52,000 daltons is also obtained from such cells and is in large part identical to the NH2-terminal end of the first glycoprotein. The presence, in a biological specimen, of antibody to the antigenic determinant of either of these proteins is indicative of the presence of cells infected by human T cell leukemia virus. An assay for the antibody is a useful diagnostic procedure for determining such infection in biological specimens.
452872
Essex Myron E.
Lee Tun-Hou
President And Fellows Of Harvard College
Smart & Biggar
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