Method and reagent for inhibiting viral replication

Details Method and reagent for inhibiting viral replication Method and reagent for inhibiting viral replication

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/70 (2006.01) A61K 39/29 (2006.01) C07H 19/06 (2006.01) C07H 21/02 (2006.01) C07K 14/08 (2006.01) C12N 5/10 (2006.01) C12N 7/00 (2006.01) C12N 7/04 (2006.01) C12N 15/10 (2006.01) C12N 15/85 (2006.01) C12N 15/86 (2006.01) C12P 19/34 (2006.01) C12Q 1/68 (2006.01) C12Q 1/70 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2135646

2135646 9323569 PCTABS00028 Enzymatic RNA molecules which specifically cleave a picornavirus RNA, an immunodeficiency virus RNA in a gene required for viral replication, e.g., the vif, nef, tat or rev gene regions, RNA of a hepatitis virus, T-cell leukemia virus RNA, RNA of a hepatitis C virus, mRNA or rhRNA of a cytomegalovirus, an influenza virus RNA, and a herpes simplex virus mRNA molecule; and methods and reagents useful in selection and optimization of ribozymes. In particular, the enzymatic RNA molecule is formed in a hammerhead motif, in the motif of a hairpin, hepatitis delta virus, group I intron or RNaseP-like RNA. The figure is a diagrammatic representation of an enzymatic RNA molecule in the hammerhead motif.

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