Method and reagent for sulfurization of organophosphorous...

Details Method and reagent for sulfurization of organophosphorous... Method and reagent for sulfurization of organophosphorous...

C - Chemistry, Metallurgy

07

F

252/43, 260/458.

C07F 9/165 (2006.01) C07F 9/40 (2006.01) C07F 9/655 (2006.01) C07F 9/6561 (2006.01) C07H 21/00 (2006.01) C08J 3/24 (2006.01)

Patent

CA 2011430

A composition suitable for sulfurizing an organophosphite. The reagent comprises a solution of sulfur and a tertiary amine, in a suitable solvent such as carbon disulfide. The tertiary amine is preferably an optionally substituted trialkyl amine, for example triethylamine or diisopropylamine. A method is also provided in which phosphites or phosphorous esters are sulfurized to their corresponding phosphorothioates or phosphonothioates, respectively, using compositions of the present invention. This method has particular application to produce internucleotide phosphorothioate or phosphonothioate bonds in a nucleotide multimer.

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