Method and reagents for the treatment of diseases or...

Details Method and reagents for the treatment of diseases or... Method and reagents for the treatment of diseases or...

C - Chemistry, Metallurgy

12

N

C12N 15/00 (2006.01) C07K 14/47 (2006.01) C12N 9/00 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2324421

Nucleic acid molecule which modulates the synthesis, expression and/or stability of an mRNA encoding for angiogenic factors selected from aryl hydrocarbon nuclear transport (ARNT), intergrin subunit beta 3 (.beta.3), integrin subunit alpha 6 (.alpha.6) and tie - 2RNA. This invention further provides a treatment for indications related to angiogenesis using the nucleic acid molecules.

L'invention se rapporte à une molécule d'acide nucléique qui module la synthèse, l'expression et/ou la stabilité d'un ARNm codant pour des facteurs angiogéniques sélectionnés parmi un transporteur nucléaire aryle-hydrocarbure (ARNT), une sous-unité intégrine bêta 3 (.beta.3), une sous-unité intégrine alpha 6 (.alpha.6) et de l'ARN du récepteur "tie-2". L'invention se rapporte également à un traitement des affections associées à l'angiogenèse faisant usage de ces molécules d'acide nucléique.

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