Method and support for biological analysis using...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01) C12Q 1/26 (2006.01)

Patent

CA 2453663

The invention concerns a method for analysing DNA or RNA biological targets, comprising the following steps: a) contacting the targets to be analysed (ICAM-20) with oligonucléotide probes (ISIS) marked with a cofactor A of an enzyme E; b) adding to the reaction medium the enzyme E corresponding to the cofactor A and a substrate S of the enzyme E, the substrate S being converted by the enzyme E into a compound C; c) measuring a signal representing the activity of the enzyme E on the substrate S, for example fluorescence intensity (I) of the substrate S; and d) comparing said signal with the signal obtained when contacting the oligonucleotide probes marked with the cofactor A (ISIS) of the enzyme E and the substrate S, in similar conditions, but in the absence of the targets, the difference between the two signals indicating the presence of complementary targets (ICAM-20) of the oligonucleotide probes.

L'invention concerne un procédé d'analyse de cibles biologiques de type ADN ou ARN, qui comprend les étapes suivantes :a) mettre en contact les cibles à analyser (ICAM-20) avec des sondes oligonucléotidiques marquées (ISIS) par un cofacteur A d'une enzyme E ;b) ajouter au milieu réactionnel l'enzyme E correspondant au cofacteur A et un substrat S de l'enzyme E, le substrat S étant converti par l'enzyme E en un composé C ;c) mesurer un signal représentatif de l'activité de l'enzyme E sur le substrat S, par exemple l'intensité de fluorescence (I) du substrat S ; et d) comparer ce signal avec le signal obtenu lorsqu'on met en contact les sondes oligonucléotidiques marquées par le cofacteur A (ISIS) avec l'enzyme E et le substrat S, dans les mêmes conditions, mais en l'absence des cibles, la différence entre les deux signaux indiquant la présence de cibles complémentaires (ICAM-20) des sondes oligonucléotidiques.

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